Cristina M. Murray-Krezan, PhD, MS, BS

  • Associate Professor of Medicine
  • Co-Director, Center for Clinical Trials & Data Coordination
  • Associate Director for Clinical Trials, CRHC Data Center

Cristina Murray-Krezan, PhD, joined the faculty at Pitt in 2021 where she is a biostatistician and Associate Professor of Medicine. She is a member of the Center for Clinical Trials and Data Coordination and the Center for Research on Health Care. She has expertise in clinical trials and complex study designs integrating medical and behavioral treatments for substance use disorders and she specializes in research aimed to promote health equity and accessibility in underserved and marginalized populations. She currently directs statistical and data coordination activities for several clinical trials and observational studies.

Dr. Murray-Krezan is a member of the PCORI Clinical Trials Advisory Panel. She serves on two committees for the Society for Clinical Trials and is a longtime member of the American Statistical Association and the International Biometric Society. In 2016, she co-founded the University of New Mexico Statistics and Data Coordinating Center and served as its Director from 2016-2021. Prior to her academic career, she was a biostatistician at Emmes in Rockville, MD where she worked in early phase vaccine and treatment clinical trials for malaria and other tropical diseases.

Dr. Murray-Krezan plays the flute and piano and imparted her ability and love for music to her children. She loves hiking and in July 2021 completed her highest hike to date up Wheeler Peak in the Sangre de Cristo mountains near Taos, NM (13,167 ft).

Education & Training

  • BS, Astrophysics, University of New Mexico, 2001
  • MS, Statistics, University of Virginia, 2006
  • PhD, Statistics, University of New Mexico, 2021

Representative Publications

Page K, Murray-Krezan C, Leeman L, Carmody M, Stephen JM, Bakhireva LN. Prevalence of marijuana use in pregnant women with concurrent opioid use disorder or alcohol use in pregnancy. Addict Sci Clin Pract. 2022 Jan 6;17(1):3.

This study assessed the prevalence of marijuana use among a cohort of pregnant women with OUD and/or who consumed alcohol during pregnancy. We found a relatively high prevalence and frequency of marijuana use indicating the need for ongoing risk reduction strategies for addressing marijuana use during pregnancy.

Meredith LS, Komaromy MS, Cefalu M, Murray-Krezan C, Page K, Osilla KC, Dopp AR, Leamon I, Tarhuni L, Hindmarch G, Jacobsohn V, Watkins KE; CLARO Study Group. Design of CLARO (Collaboration Leading to Addiction Treatment and Recovery from other Stresses): A randomized trial of collaborative care for opioid use disorder and co-occurring depression and/or posttraumatic stress disorder. Contemp Clin Trials. 2021 Mar 10:106354.

This protocol paper describes the CLARO study, a randomized controlled trial to assess the effectiveness of care coordination vs. enhanced usual care in the primary care setting for persons with opioid use disorder and co-occurring depression and/or PTSD. This is an ongoing study.

Page-Reeves J, Murray-Krezan C, Regino L, Perez J, Bleecker M, Perez D, Wagner B, Tigert S, Bearer EL, Willging CE. A randomized control trial to test a peer support group approach for reducing social isolation and depression among female Mexican immigrants. BMC Public Health. 2021 Jan 11;21(1):119.

This publication describes the protocol for the randomized controlled trial Tertulias (Spanish for conversational groups) intervention vs control to address social isolation and depression in female Mexican immigrants. This is an ongoing study.

Crisanti AS, Murray-Krezan C, Reno J, Killough C. Effectiveness of Peer-Delivered Trauma Treatment in a Rural Community: A Randomized Non-inferiority Trial. Community Ment Health J. 2019 Oct;55(7):1125-1134.

Results from this PCORI-funded randomized non-inferiority trial showed that peer support workers delivered the intervention Seeking Safety as effectively as licensed behavioral health clinicians to a population of rural people with PTSD and/or substance use disorder. Both delivery models resulted in decreased PTSD symptoms and increased coping skills at the 6-month post-baseline assessment.

Click here for a more complete bibliography of Dr. Murray-Krezan’s works.

Research Interests

  • Substance use disorders
  • Statistics and data coordinating centers
  • Clinical trials
  • Methods to adjust for informative dropout