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Pain is the hallmark symptom of sickle cell disease (SCD). Adults with the disease experience acute and chronic pain that is often poorly managed, leading to disability, chronic opioid therapy, and compromised quality of life. To develop culturally adapted pain interventions and improve pain management, there is a critical need to better understand the influence of sociocultural factors on pain-related outcomes. This presentation will focus on the impact of discrimination on psychological, behavioral, and pain-related outcomes in adults with SCD.